We are pleased to announce the virtual Dynein 2021 International Workshop which will be held online on 8th/9th September 2021. This free, live meeting will bring together scientists with an interest in dynein motors to share novel research results and establish and develop new collaborations. Our goal is to provide a venue to encourage discussions across all areas of dynein biology and extend opportunities for junior researchers to participate in the field despite the difficulties imposed by the current pandemic.
Dynein 2021 will be a community meeting. All talks and posters will be selected from abstracts. Round table and networking events will provide a chance to meet others in the field. Early career researchers (PhD, Postdoc and Junior Faculty) are eligible to be considered for the newly established Ian and Barbara Gibbons Medal for the best contribution to the field since the last dynein meeting.
Registration for the meeting is now open. The deadline to apply to give a talk and/or apply for a Gibbons Award is 1st July 2021
Dyneins are gigantic motor proteins that power directional movement along microtubules. First identified in 1965, their large size and complexity have for many years made the elucidation of their cellular and molecular mechanisms challenging. The pace of dynein research has increased dramatically in the last decade and the field now has unprecedented insights into the structure, mechanism, and cell biology of these giant motors. The dynein superfamily is functionally diverse but can be divided into axonemal dyneins, that work in ensembles to power the beating movement of cilia and flagella, and cytoplasmic dyneins that participate in moving intracellular cargos within the cytoplasm or within cilia and flagella.
We are in an unprecedented era of understanding the structure of both types of dyneins thanks to the revolution in cryo-EM. We now have structures of cytoplasmic and axonemal dyneins, and an increasing knowledge of the architecture of the cilium. Advances in in vitro reconstitutions and precise biophysical measurements have revealed surprising details about how dyneins step along microtubules, produce force, and are regulated by intramolecular and intermolecular interactions. Cell biological studies have revealed a plethora of unanticipated physiological roles for cytoplasmic dyneins, and surprisingly elaborate pathways for the assembly of axonemal dyneins. Genetic studies are increasing our knowledge of how defects in dynein functions underlies human diseases. By all measures, we are in a golden era of breakthroughs for understanding the roles of dynein in biology!
The Dynein International Workshop has been held every four years in Japan since 2005. It brings together the broader dynein field to share novel results, network with others, open new collaborations across disciplines, and stay abreast of the latest research. The dynein workshop has been a cornerstone of the field for almost two decades. Its continuation will ensure vital communication and collegiality, and provide opportunities for junior researchers to disseminate their work and establish new connections. With the advent of the COVID pandemic in 2020 preventing travel across the globe, the next International Workshop on Dynein will be held online in 2021 in order to ensure this vital resource for the field continues.
The scope of the Virtual International Workshop on Dynein 2021 will be the molecular and cellular mechanisms that control, distribute, and regulate dynein activity in cellular homeostasis and human disease. The meeting will broadly cover both cytoplasmic and ciliary/axonemal dyneins and their cellular functions. The live program will cover two short (4 hour) days, timed so participants can attend from all over the world. There will be two talk sessions each day, with all talks selected from abstracts. Talks will be recorded and available to participants after the live session. Round table/networking sessions will facilitate interactions between participants. Poster presentations will be recorded and available to download, with questions and discussion taking place online throughout the meeting.
A focus of the meeting will be to aid and integrate early career researchers with a strong interest in dynein biology into the larger dynein research community.
Meeting topics will include:
- Cytoplasmic dynein regulation
- Cytoplasmic dynein cargo interactions
- Dynein motor biophysics
- Cytoplasmic and ciliary dynein structures
- Intraflagellar transport
- Mechanisms of cilia beating and axonemal dynein regulation
- Dynein assembly
- Dyneins in human disease
Registration is open. The deadline to apply to give a talk is 1st July 2021
Dates of the meeting: September 8th & 9th 2021
Live Programme (4 hours each day for 2 days):
- 80 min Talk session (each talk 15+5 mins)
- 10 min Break
- 60 min Round-table discussions/Networking
- 10 min Break
- 80 min Talk session
Start and end times:
- 6:00 AM-10:00AM San Francisco,
- 9:00AM-1:00PM New York,
- 2:00-6:00PM London,
- 3:00-7:00 PM Berlin,
- 6:30 PM-10:30PM Mumbai,
- 10:00PM-2:00AM Tokyo,
- 11:00PM-3:00AM Sydney (note end times in Tokyo and Sydney are +1 day)
All talks will be selected from abstracts. Four talks per session (each is 15 mins + 5 mins for questions). All talks will be hosted live via Zoom Webinar.
Poster presenters will submit a pdf poster and a 5-minute video presentation. Attendees will watch at their leisure and contact the presenter via email or a Slack channel. Participants will be able to contact poster presenter directly and set up a time to talk one-on-one.
Round table discussions present an opportunity for meeting attendees to interact with junior and senior group leaders in the cytoplasmic and axonemal dynein fields (see list below). These sessions will be limited to small groups to facilitate connections with the designated table leader. Each covers a distinct theme, ranging from active research questions to career topics, but leaders and participants are encouraged to allow the discussion to develop organically in any interesting direction they choose. The round tables are particularly encouraged for junior scientists as an opportunity to meet and discuss relevant topics of interest for their future careers. When you register please select all those round tables you would be interested in attending. Slots will be filled on a first come, first serve basis.
|Roop Mallik||Dynein Biophysics|
|Ron Vale||Career as an Academic Scientist|
|Erika Holzbaur||Cytoplasmic Dynein in Disease|
|Sam Reck-Peterson||Career as an Academic Scientist|
|Thomas Surrey||In Vitro Reconstitution|
|Ken’ya Furuta||Engineering Dyneins|
|Morgan DeSantis||Dynein Regulation|
|Tomomi Kiyomitsu||Dynein in Mitosis|
|Vaishnavi Ananthanarayanan||Single Molecule Studies of Dynein|
|Susan Dutcher||Preassembly of Axonemal Dyneins|
|Guangshuo Ou||IFT Dynein in C. elegans|
|John Wallingford||Axonemal Dynein Assembly|
|Gaia Pigino||Structural Biology of IFT|
|Alan Brown and Rui Zhang||Structural Biology of Axonemes|
|Miriam Schmidts||Genetics of Human Ciliary Dynein Diseases|
|Joe Howard||Mechanisms of ciliary beating|
Those not attending a round table are welcome to join a virtual “coffee” room which will allow informal discussions.
The Ian and Barbara Gibbons Award
Scope: The award is for a published piece of work by a junior researcher or researchers that has made a significant impact in the dynein field since the last International Workshop.
Eligibility: Any current PhD student, postdoc or junior faculty (defined as pre-tenure or within 5 years of starting their lab) who has published a first author paper in the dynein field since the last dynein meeting in 2017. Junior faculty who have made a major experimental contribution to a paper on which they are corresponding author are also eligible.
Application: Candidates need to register for the meeting. They will be asked to write a short (max 500 word) justification listing the relevant paper, explaining the work’s impact and their contribution. The deadline for applications is July 1st 2021.
Many papers are the result of collaborations between multiple authors. We encourage applications that recognise this. Either all relevant authors can apply separately and cross reference each other’s applications. Alternatively, one author can apply, list all those who should be considered and their contributions.
Selection: All applications will be considered by the Organizing Committee. The awardee(s) will be selected based on the work considered to have made the greatest contribution to the dynein field since the last dynein international workshop. The Committee will consider the impact of the work and the contribution of the authors. Senior authors may be contacted to clarify the role played by the candidates.
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